Changes in Management After 18F-DCFPyL PSMA PET in Patients
Por um escritor misterioso
Last updated 16 abril 2025

Prostate-specific membrane antigen (PSMA) tracers have increased sensitivity in the detection of prostate cancer, compared with conventional imaging. We assessed the management impact of 18F-DCFPyL PSMA PET/CT in patients with prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP) and report early biochemical response in patients who underwent radiation treatment. Methods: One hundred patients were enrolled into a prospective study, with a prior RP for prostate cancer, a PSA of 0.2–2.0 ng/mL, and no prior treatment. All patients underwent diagnostic CT and PSMA PET/CT, and management intent was completed at 3 time points (original, post-CT, and post-PSMA) and compared. Patients who underwent radiotherapy with 6-mo PSA response data are presented. Results: Ninety-eight patients are reported, with a median PSA of 0.32 ng/mL (95% CI, 0.28–0.36), pT3a/b disease in 71.4%, and an International Society of Urological Pathology grade group of at least 3 in 59.2%. PSMA PET/CT detected disease in 46.9% of patients, compared with 15.5% using diagnostic CT (PSMA PET, 29.2% local recurrence and 29.6% pelvic nodal disease). A major change in management intent was higher after PSMA than after CT (12.5% vs. 3.2%, P = 0.010), as was a moderate change in intent (31.3% vs. 13.7%, P = 0.001). The most common change was an increase in the recommendation for elective pelvic radiation (from 15.6% to 33.3%), nodal boost (from 0% to 22.9%), and use of concurrent androgen deprivation therapy (ADT) (from 22.9% to 41.7%) from original to post-PSMA intent because of detection of nodal disease. Eighty-six patients underwent 18F-DCFPyL–guided radiotherapy. Fifty-five of 86 patients either did not receive ADT or recovered after ADT, with an 18-mo PSA response from 0.32 to 0.02 ng/mL; 94.5% of patients had a PSA of no more than 0.20 ng/mL, and 74.5% had a PSA of no more than 0.03 ng/mL. Conclusion: 18F-DCFPyL PET/CT has a significant impact on management intent in patients being considered for salvage radiotherapy after RP with PSA recurrence. Increased detection of disease, particularly in the pelvic lymph nodes, resulted in increased pelvic irradiation and concurrent ADT use. Early results in patients who are staged with 18F-DCFPyL PET/CT show a favorable PSA response.

JCM, Free Full-Text

The Impact of 18F-DCFPyL PSMA PET-CT in the Management of Prostate

AI developed for staging patients with prostate cancer

PSMA PET imaging in the diagnosis and management of prostate
Development of PSMA-1007-Related Series of 18F-Labeled Glu-Ureido

A Phase 2/3 Prospective Multicenter Study of the Diagnostic

PDF] Predictors of 18F-DCFPyL PET/CT Positivity in Patients with

Frontiers Evaluation of 18F-DCFPyL PSMA PET/CT for Prostate

PET Imaging for Prostate Cancer

PSMA PET in Imaging Prostate Cancer. - Abstract - Europe PMC

Flowchart of all screened patients on eligibility

Event-free survival after 68 Ga-PSMA-11 PET/CT in recurrent

Prospective Evaluation of 18F-DCFPyL PET/CT in Detection of High
Recomendado para você
-
Empire Kosher Classic Slow Roasted Turkey Breast, 7 oz16 abril 2025
-
Medical Supplies: Food or Pharma Film - 140mm Pet/Foil/PP (3316 abril 2025
-
Purina Pro Plan High Protein Sensitive Skin & Stomach Dry Cat Food16 abril 2025
-
Paraguay 5 (x) 7 Pcs Coin Set, 1 5 10 50 100 500 1000 Guaranies16 abril 2025
-
Animal People:
Andrew Dale16 abril 2025 -
Proposta por Gómez? Verdão começa a se movimentar no mercado16 abril 2025
-
RD Bar & Grill16 abril 2025
-
There Will Be Blood16 abril 2025
-
Destination Resources16 abril 2025
-
Mysteries that cross genres16 abril 2025
você pode gostar
-
Ever After High Mirror Beach Apple White16 abril 2025
-
Tempolábil - Dicio, Dicionário Online de Português16 abril 2025
-
Oshi No Ko's Incredible Debut and Disappointing Follow Through16 abril 2025
-
Smart Fortwo: preços do famoso minicarro16 abril 2025
-
Existe bons modos para se usar uma classe? - Programação e16 abril 2025
-
Kath🩸 BG3 brainrot on X: why is there so much misconception16 abril 2025
-
Homem-Aranha 2 – Papo de Cinema16 abril 2025
-
Fictional Gran Turismo Race Cars you wished were real16 abril 2025
-
73 Scp Foundation ideas in 202316 abril 2025
-
The Rising of the SHIELD HERO: RERISE Gameplay [JP] - RPG (Android)16 abril 2025