An Historical Review of Steps and Missteps in the Discovery of
Por um escritor misterioso
Last updated 29 março 2025

The epidemic of obesity cries out for strategies to prevent it, and for treatment when prevention fails. Yet despite the obvious need, the path to developing anti-obesity medications is strewn with failures. This review examines some historical developments in the management of obesity prior to the 20th century followed by more recent efforts to find a “cure.” Since obesity has been a human disease since paleolithic times, discussion of treatment prior to the scientific revolution in about 1500 CE will include comments on treatment of obesity in Grecian Medicine and the Treatment of Sancho “The Fat” King of Leon in 10th century northern Spain. We will then trace treatment trends through time, ending in the early 21st century. In the first half of the 20th century there were 3 main themes associated with drug treatment of obesity: use of thyroid hormones, the interlude with dinitrophenol as drug regulation was beginning to expand, and the introduction of amphetamines and Rainbow Pills. In the second half of the 20th century many new treatment approaches were explored as the scientific basis for understanding regulation of food intake expanded, particularly after the discovery of leptin in 1994. The fact that amphetamine could be addictive led to the search for compounds that acted in the central nervous system with retained the anorectic properties but were not addictive. Both anti-depressant and anticonvulsive drugs were evaluated with disappointing results. The idea of enhancing energy expenditure with thermogenic drugs was pursued but led to a dead end. Peptides, metabolic drugs and drugs that act on the gastrointestinal track are currently under exploration. This chapter makes an effort to answer the question of why it has been so difficult to develop effective medications for the management of obesity. For complete coverage of all related areas of Endocrinology, please visit our on-line FREE web-text, WWW.ENDOTEXT.ORG.

Writing & Language Development Center Editing and Proofreading

The Fearless Organization: Creating Psychological Safety in the
How It All Started: China's Early Coronavirus Missteps - WSJ

LLM Powered Autonomous Agents

The Mortgage Underwriting Process

The Importance of Data Driven Decision Making for Business

Hard-Headed Man Science History Institute

Historical Method: 5 step process historians use to write history

OSN expands channel's lineup with Warner Bros. Discovery
Writer's Digest, September 2014, Volume 94, No. 6 FEATURES: The Writer's Guide to Everything Past Perfect Our 5-step guide to digging up details will

Writer's Digest September 2014 Digital Download

What Is Global Expansion, and What Strategy to Use?

Guttenberg plagiarism scandal - Wikipedia

8 tips for dealing with employee mistakes - TestGorilla
Recomendado para você
-
Gmail - Bronstein Mega Méier29 março 2025
-
The Technique of Calculation - Chess Lessons29 março 2025
-
The Top 10 Games Of The 1950s - Chess Lessons29 março 2025
-
Checkmate Grandmaster! - Winning In The Opening - Chess Lessons29 março 2025
-
1984 - ™29 março 2025
-
Sabres get 'goat head' swagger back to beat Lindy Ruff's Devils29 março 2025
-
Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum29 março 2025
-
Apartamento na Rua Dias da Cruz, 335, Méier em Rio de Janeiro, por R$ 255.000 - Viva Real29 março 2025
-
Gmail - Confirmação de Agendamento - Bronstein Medicina Diagnóstica29 março 2025
-
Play Like A World Champion: Botvinnik, Smyslov And Tal - Chess29 março 2025
você pode gostar
-
Minecraft Bedrock and Java Editions Coming to Xbox Game Pass for PC29 março 2025
-
Imagem: Fnaf Withered Foxy Full Body29 março 2025
-
What Do You Meme. Game of Thrones Expansion Pack29 março 2025
-
Ashley Knight Armor - Characters & Art - Resident Evil 4 Resident evil 4 ashley, Ashley graham resident evil, Resident evil29 março 2025
-
Counter-Strike: Global Offensive Review - GameSpot29 março 2025
-
No Game No Life - Shiro : r/AnimeFigures29 março 2025
-
Assistir Shijou Saikyou no Daimaou Murabito A ni Tensei Suru Todos29 março 2025
-
Dr. Parking 4 – Apps no Google Play29 março 2025
-
cs-10-things-you-didn-t-know-about-the-court-of-owls.jpg29 março 2025
-
Level 4 Logo Quiz Answers - Bubble - DroidGaGu Logo quiz, Logo quiz answers, Logo quiz games29 março 2025