Biomedicines, Free Full-Text
Por um escritor misterioso
Last updated 23 fevereiro 2025
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Alpha-synuclein’s role in diseases termed “synucleinopathies”, including Parkinson’s disease, has been well-documented. However, after over 25 years of research, we still do not fully understand the alpha-synuclein protein and its role in disease. In vitro cellular models are some of the most powerful tools that researchers have at their disposal to understand protein function. Advantages include good control over experimental conditions, the possibility for high throughput, and fewer ethical issues when compared to animal models or the attainment of human samples. On the flip side, their major disadvantages are their questionable relevance and lack of a “whole-brain” environment when it comes to modeling human diseases, such as is the case of neurodegenerative disorders. Although now, with the advent of pluripotent stem cells and the ability to create minibrains in a dish, this is changing. With this review, we aim to wade through the recent alpha-synuclein literature to discuss how different cell culture setups (immortalized cell lines, primary neurons, human induced pluripotent stem cells (hiPSCs), blood–brain barrier models, and brain organoids) can help us understand aggregation pathology in Parkinson’s and other synucleinopathies.
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An overview on nanoparticles used in biomedicine and their
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Free Radicals Brain Injury - Colaboratory
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License Key File Scavenger Version 4.1 - Colaboratory
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Cellular and molecular biomarkers of long COVID: a scoping review
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SARS-CoV-2 Initiates Programmed Cell Death in Platelets
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Changes in nanomechanical properties of single neuroblastoma cells
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Generate: Biomedicines - Fonts In Use
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Serial Para Internet Manager 6.21 - Colaboratory
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Decoding the Patterns of Self and Nonself by the Innate Immune
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Biomedicines An Open Access Journal from MDPI
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Biomedicines, Free Full-Text
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Medical viruses: diagnostic techniques, Virology Journal
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