Cancers, Free Full-Text

Neuroblastoma is the most common extracranial solid pediatric tumor, with around 15% childhood cancer-related mortality. High-risk neuroblastomas exhibit a range of genetic, morphological, and clinical heterogeneities, which add complexity to diagnosis and treatment with existing modalities. Identification of novel therapies is a high priority in high-risk neuroblastoma, and the combination of genetic analysis with increased mechanistic understanding—including identification of key signaling and developmental events—provides optimism for the future. This focused review highlights several recent findings concerning chromosomes 1p, 2p, and 11q, which link genetic aberrations with aberrant molecular signaling output. These novel molecular insights contribute important knowledge towards more effective treatment strategies for neuroblastoma.

Journal of Cancer Research and Clinical Oncology

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Cancer-immune interactions in ER-positive breast cancers: PI3K pathway alterations and tumor-infiltrating lymphocytes, Breast Cancer Research

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Cancers, Free Full-Text

Kidney Cancer: Symptoms, Signs, Causes & Treatment

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Cancers, Free Full-Text

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Detecting cell-of-origin and cancer-specific methylation features of cell- free DNA from Nanopore sequencing, Genome Biology

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