Cancers, Free Full-Text

Ubiquitin-like, containing PHD and RING finger domain, (UHRF) family members are overexpressed putative oncogenes in several cancer types. We evaluated the protein abundance of UHRF family members in acute leukemia. A marked overexpression of UHRF1 protein was observed in ALL compared with AML. An analysis of human leukemia transcriptomic datasets revealed concordant overexpression of UHRF1 in B-Cell and T-Cell ALL compared with CLL, AML, and CML. In-vitro studies demonstrated reduced cell viability with siRNA-mediated knockdown of UHRF1 in both B-ALL and T-ALL, associated with reduced c-Myc protein expression. Mechanistic studies indicated that UHRF1 directly interacts with c-Myc, enabling ALL expansion via the CDK4/6-phosphoRb axis. Our findings highlight a previously unknown role of UHRF1 in regulating c-Myc protein expression and implicate UHRF1 as a potential therapeutic target in ALL.

Multimodal analysis of cell-free DNA whole-methylome sequencing

10 Year Cancer Survivor Card Remission Card Cancer Free Card

ONE year and Cancer FREE!

Basic Information About Breast Cancer

Sotorasib for Lung Cancers with KRAS p.G12C Mutation

Multi-omics integrated circulating cell-free DNA genomic

Cancer Free Posters for Sale

Join a FREE Breast Cancer Survivorship Program

Blood Test for Cancer Screening

Cancer Horoscopes: Daily & Today

Cancer-Free with Food: A Step-by-Step by Werner Gray, Liana

Pathology Outlines - Carcinoma-general