Cancers, Free Full-Text
Por um escritor misterioso
Last updated 30 março 2025

Transforming growth factor-beta (TGFB) is a critical regulator of normal haematopoiesis. Dysregulation of the TGFB pathway is associated with numerous haematological malignancies including myelofibrosis, acute myeloid leukaemia, and lymphoid disorders. TGFB has classically been seen as a negative regulator of proliferation in haematopoiesis whilst stimulating differentiation and apoptosis, as required to maintain homeostasis. Tumours frequently develop intrinsic resistant mechanisms to homeostatic TGFB signalling to antagonise its tumour-suppressive functions. Furthermore, elevated levels of TGFB enhance pathogenesis through modulation of the immune system and tumour microenvironment. Here, we review recent advances in the understanding of TGFB signalling in B-cell malignancies with a focus on the tumour microenvironment. Malignant B-cells harbour subtype-specific alterations in TGFB signalling elements including downregulation of surface receptors, modulation of SMAD signalling proteins, as well as genetic and epigenetic aberrations. Microenvironmental TGFB generates a protumoural niche reprogramming stromal, natural killer (NK), and T-cells. Increasingly, evidence points to complex bi-directional cross-talk between cells of the microenvironment and malignant B-cells. A greater understanding of intercellular communication and the context-specific nature of TGFB signalling may provide further insight into disease pathogenesis and future therapeutic strategies.

Cancer Horoscopes: Daily & Today

Cancer-Free, Third Edition by Bill Henderson - Audiobook

Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer

Home - Free ME from Lung Cancer

Cell-free nucleic acids as biomarkers in cancer patients

White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

Remission, cancer-free, no evidence of disease: What's the difference?
Blood Test for Cancer Screening
Prostate Cancer: Symptoms, Causes & Treatment

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries - Sung - 2021 - CA: A Cancer Journal for Clinicians - Wiley Online Library
Recomendado para você
-
South India Matka – Apps on Google Play30 março 2025
-
GOLDEN MATKA's Stats and Analytics30 março 2025
-
Billa-Kalyan Matka App – Apps on Google Play30 março 2025
-
Himachal Water Matka Pot Indian Matka Wooden Wood Jug Matka30 março 2025
-
MATKA GAME OFFICIAL APP APK (Android App) - Free Download30 março 2025
-
General Paint Matka / CL 1916A / #a99358 Hex Color Code, RGB and30 março 2025
-
VGM Essentials: SARE (Compact Disc)30 março 2025
-
Gokul Cop Matka Pavali Gokul - Cm Matka Pavali-63230 março 2025
-
Buy MRP Multipurpose Matka Stand Pot Stand (Red) Online at Low30 março 2025
-
MG-Milan Starline Online Matka - Latest version for Android30 março 2025
você pode gostar
-
Dragon Ball Z Kai: A série retorna em abril com a fase “Majin Boo” - JWave30 março 2025
-
Saikyou Tank no Meikyuu Kouryaku: Tairyoku 9999 no Rare Skill-mochi Tank, Yuusha Party wo Tsuihou Sareru30 março 2025
-
Pessoa jogando jogo de tabuleiro de xadrez, imagem do conceito de mulher de negócios segurando peças30 março 2025
-
Getting Over It Custom Maps30 março 2025
-
Quem Venceria? Goku Super Saiyajin 3 Ou Broly Lendário Super Saiyajin30 março 2025
-
Custom Roblox Mini plush toy - Portugal30 março 2025
-
10 Sugestões de Jogos para PC30 março 2025
-
FAIRY TAIL: 100 Years Quest30 março 2025
-
Brasil e Chile já estão nas semifinais do Pan-Americano Santiago30 março 2025
-
IMAGEM PROIBIDA NO MINECRAFT - MEMES EM IMAGENS GAMES #12530 março 2025