Chemosensors, Free Full-Text

Alcoholic beverages contaminated with scopolamine (SCP) are often employed for criminal purposes due to their sedative effect. The determination of the residual levels of SCP in body fluids (e.g., urine) can help to track possible victims of induced ingestions. Biological sample analysis usually requires a preconcentration step to enhance their detectability and to provide sample clean-up. Molecularly imprinted polymers (MIPs) in lieu of conventional solid sorbents represent an enhancement of selectivity, due to their specific recognition sites. Additionally, the adaptation of the solid-phase extraction (SPE) cartridge into a disposable pipette tip extraction (DPX) contributes to the miniaturization of the sample preparation step. Herein, an analytical method for the determination of SCP in synthetic urine samples via the integration of molecularly imprinted solid-phase extraction (MISPE) with DPX as a preconcentration step prior to capillary electrophoresis analysis (also known as MISPE-DPX-CE) is presented. The extraction and elution steps were optimized using a factorial design. Using the optimized conditions, a preconcentration factor of 20 was obtained, leading to a working range of 0.5–6 µM with LOD of 0.04 µM and repeatability of 6.4% (n = 7) and adequate recovery values (84 and 101%) The proposed MISPE-DPX-CE approach was successfully applied to selective extraction, preconcentration, and determination of SCP in synthetic urine samples.

Full article: Medicinal Importance, Coordination Chemistry with

Amity University Admit Card 2017 Download - Colaboratory

Full article: Recent advances in polymeric chemosensors for the

Optical Chemosensors: Principles, Chemistry, Strategies, and

Recent progress in chemosensors based on pyrazole derivatives

Frontiers A Colorimetric Chemosensor Based on a Nozoe Azulene

Fluorescent chemosensors: the past, present and future - Chemical

Serial PEF measurement is superior to cross-shift change in

Chemosensors February 2023 - Browse Articles