The Safety of High Dose Labetalol in the Pregnant Population

Hypertension in pregnancy is one of the leading causes of maternal mortality and rapid treatment is critical. Treatment of emergent hypertensive crises in pregnancy is limited to only three medications, one of which is labetalol. Current literature recommends a daily maximum intravenous labetalol dose of 300 mg per day. However, this maximum dose has not been studied in pregnancy where higher doses may be required.

Oral nifedipine vs. intravenous labetalol for treatment of pregnancy‐induced severe pre‐eclampsia - Shi - 2016 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library

Hydralazine vs labetalol for the treatment of severe hypertensive disorders of pregnancy. A randomized, controlled trial - ScienceDirect

Labetalol side effects and how to avoid them

Labetalol: Uses, Side Effects, Dosage & Reviews

Drug therapy for the treatment of very high blood pressure in pregnancy

IV labetalol and oral nifedipine in acute control of severe hypertension in pregnancy–A randomized controlled trial - ScienceDirect

Safety and efficacy of continuous intravenous labetalol for blood pressure control in neurosurgical patients - Raywat Noiphithak, Gahn Duangprasert, Sasikan Sukhor, Pichayaphong Durongkaweroj, Vich Yindeedej, 2023

The Safety of High Dose Labetalol in the Pregnant Population

Labetalol Tablets: Package Insert

LABETALOL HYDROCHLORIDE injection