Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Frontiers The Coordination of Local Translation, Membranous

Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR

RNA-binding proteins balance brain function in health and disease

Fragile X syndrome: From protein function to therapy - Bagni

Fragile X Mental Retardation Protein Induces Synapse Loss through

Targeted treatments for fragile X syndrome

Deregulation of ER-mitochondria contact formation and

IJMS, Free Full-Text

Molecular mechanisms behind mRNA localization in axons

Fragile X mental retardation protein in intrahepatic