Advanced Quantitative Fluorescence Microscopy to Probe the Molecular Dynamics of Viral Entry, Science Lab

Viral entry into the host cell requires the coordination of many cellular and viral proteins in a precise order. Modern microscopy techniques are now allowing researchers to investigate these interactions with higher spatiotemporal resolution than ever before. Here we present two examples from the field of HIV research that make use of an innovative quantitative imaging approach as well as cutting edge fluorescence lifetime-based confocal microscopy methods to gain novel insights into how HIV fuses to cell membranes and enters the cell.

Labeling of virus components for advanced, quantitative imaging analyses - Sakin - 2016 - FEBS Letters - Wiley Online Library

Beyond mass spectrometry, the next step in proteomics

Peptide-Induced Fusion of Dynamic Membrane Nanodomains: Implications in a Viral Entry

Mucins Inhibit Coronavirus Infection in a Glycan-Dependent Manner

Viruses, Free Full-Text

Probing the interaction of influenza A viruses (IAVs) with cells and

Full article: Manipulation of matter with shaped-pulse light field and its applications

Frontiers Microscopic Visualization of Cell-Cell Adhesion Complexes at Micro and Nanoscale

Quantum dot as probe for disease diagnosis and monitoring - Mukherjee - 2016 - Biotechnology Journal - Wiley Online Library

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening

Detection of different viruses using fluorescent labelling and single