Molecules, Free Full-Text
Por um escritor misterioso
Last updated 14 março 2025

COVID-19 is an acute respiratory disease caused by SARS-CoV-2 that has spawned a worldwide pandemic. ADAM17 is a sheddase associated with the modulation of the receptor ACE2 of SARS-CoV-2. Studies have revealed that malignant phenotypes of several cancer types are closely relevant to highly expressed ADAM17. However, ADAM17 regulation in SARS-CoV-2 invasion and its role on small molecules are unclear. Here, we evaluated the ADAM17 inhibitory effects of cordycepin (CD), thymoquinone (TQ), and N6, N6-dimethyladenosine (m62A), on cancer cells and predicted the anti-COVID-19 potential of the three compounds and their underlying signaling pathways by network pharmacology. It was found that CD, TQ, and m62A repressed the ADAM17 expression upon different cancer cells remarkably. Moreover, CD inhibited GFP-positive syncytia formation significantly, suggesting its potential against SARS-CoV-2. Pharmacological analysis by constructing CD-, TQ-, and m62A-based drug-target COVID-19 networks further indicated that ADAM17 is a potential target for anti-COVID-19 therapy with these compounds, and the mechanism might be relevant to viral infection and transmembrane receptors-mediated signal transduction. These findings imply that ADAM17 is of potentially medical significance for cancer patients infected with SARS-CoV-2, which provides potential new targets and insights for developing innovative drugs against COVID-19.

An Introduction to Molecules and Extended Structures by Cheryl Smith

55+ Thousand Chemistry Text Royalty-Free Images, Stock Photos

Sample molecules. Chemozart generates high-quality molecular

Molecules Background. Royalty-Free Stock Image - Storyblocks

How To Determine Hybridization: A Shortcut – Master Organic Chemistry

Molecules An Open Access Journal from MDPI

Biocatalytic Construction of Chiral Pyrrolidines and Indolines via

Free Vector Structure molecule dna atom neurons scientific

NCERT Solutions Class 9 Science Chapter 3 Atoms And Molecules

Molecules An Open Access Journal from MDPI

Molecules Set of 4 Art PRINTABLES Caffeine Happiness Sleep

Molecules An Open Access Journal from MDPI

Molecules An Open Access Journal from MDPI

Molecules, Free Full-Text

Molecules An Open Access Journal from MDPI
Recomendado para você
-
COLÉGIO SÃO VICENTE DE PAULO SÃO LUÍS / MA14 março 2025
-
Contato14 março 2025
-
Período de confirmação de Matrícula 2023 termina 13/0114 março 2025
-
IEIC - Representante de Turmas 2023 - Colégio Imaculada - Mogi Mirim14 março 2025
-
Funding roundup] Supersourcing, Karomi Technology, BiofuelCircle raise early-stage deals14 março 2025
-
Amigos da Água14 março 2025
-
Seguridad-valor y honestidad-csvp14 março 2025
-
Vivek Tripathi on LinkedIn: #netzero14 março 2025
-
ERDDAP - HF radar data hourly processed in real-time of the Surface Ocean Velocity in MedSea - Make A Graph14 março 2025
-
Força Jovem X Boca Junior, Campeonato Sergipano Sub-2014 março 2025
você pode gostar
-
Assistir todos episódios de Dragon Ball Super - Legendado. Dragon ball super wallpapers, Dragon ball wallpapers, Dragon ball super14 março 2025
-
Caderno Naruto 1 Matéria 80 Folhas C/4 Kit Completo - Tem Tem Digital - Brinquedos e Papelaria, aqui tem!14 março 2025
-
Jogo da Velha - Coleção Joguinhos de Bolsa - Babebi : : Brinquedos e Jogos14 março 2025
-
How to do Oni, Stand Awakening14 março 2025
-
Think You Have Good Ears? This Video May Unnerve You14 março 2025
-
Serene Hozumi - Mother of the Goddess' Dormitory / Megami-ryou no Ryoubo-kun - v1.0, Stable Diffusion LoRA14 março 2025
-
Fritz (Gacha Edit) - Notability Gallery14 março 2025
-
Simu Liu with the respectable answer. I cannot wait to see him kill the Shang Chi movie : r/marvelstudios14 março 2025
-
Jogo de estacionamento de carro versão móvel andróide iOS apk baixar gratuitamente-TapTap14 março 2025
-
Jogo de café turco de alta qualidade, 6 xícaras e pratos decorados jogo de chá, bule, xícara de café, decoração de casa, presente de casamento. - AliExpress14 março 2025