Rac1 Regulates Neuronal Polarization through the WAVE Complex
Por um escritor misterioso
Last updated 23 abril 2025

Neuronal migration and axon growth, key events during neuronal development, require distinct changes in the cytoskeleton. Although many molecular regulators of polarity have been identified and characterized, relatively little is known about their physiological role in this process. To study the physiological function of Rac1 in neuronal development, we have generated a conditional knock-out mouse, in which Rac1 is ablated in the whole brain. Rac1 -deficient cerebellar granule neurons, which do not express other Rac isoforms, showed impaired neuronal migration and axon formation both in vivo and in vitro . In addition, Rac1 ablation disrupts lamellipodia formation in growth cones. The analysis of Rac1 effectors revealed the absence of the Wiskott–Aldrich syndrome protein (WASP) family verprolin-homologous protein (WAVE) complex from the plasma membrane of knock-out growth cones. Loss of WAVE function inhibited axon growth, whereas overexpression of a membrane-tethered WAVE mutant partially rescued axon growth in Rac1 -knock-out neurons. In addition, pharmacological inhibition of the WAVE complex effector Arp2/3 also reduced axon growth. We propose that Rac1 recruits the WAVE complex to the plasma membrane to enable actin remodeling necessary for axon growth.

Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar–Bipolar Transition

Journal of Cellular Physiology, Cell Biology Journal

Frontiers Rac1, A Potential Target for Tumor Therapy

Cells, Free Full-Text

Advances in Understanding the Molecular Mechanisms of Neuronal Polarity

Full article: Regulation of cell adhesion and migration in cortical neurons

Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation

Rac1 Pathway

STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development

Rac1 Regulates Neuronal Polarization through the WAVE Complex

Cancers, Free Full-Text
RAC1 regulated the dynamics of peripheral ORAI1-CTTN and ruffling. U2OS

Frontiers Crosstalk between the Rho and Rab family of small GTPases in neurodegenerative disorders
Full article: Tiam1 Regulates the Wnt/Dvl/Rac1 Signaling Pathway and the Differentiation of Midbrain Dopaminergic Neurons

Cells, Free Full-Text
Recomendado para você
-
Surfskate Wave23 abril 2025
-
Only 24 hours left in the IGL Coatings USA 2023 Spring Marine Sale fam!!! Have you saved yet? And don't miss out on ecoclean Precoat and…23 abril 2025
-
Solved (ii) Show that the wave-function V (2 t) = { Acos(17)23 abril 2025
-
SCAMMEI O WAVE IGL e ELE TILTOU? (deu rage comigo)23 abril 2025
-
IGL says oxygen supplies adequate for fourth COVID wave - PressReader23 abril 2025
-
Instagram photo by IGL LABS /IGL LABORATORY • Mar 22, 2021 at 3:55 AM23 abril 2025
-
SICCE XSTREAM 5000 Wave Maker Flow Pump 1320 GPH 360° Adjustable Quiet Submersible Magnetic Powerhead for Saltwater & Freshwater Tanks, Aquarium Water Circulation Pump up to 130 Gallons : Pet Supplies23 abril 2025
-
Prepared to Surf - oferece versão em inglês23 abril 2025
-
Surf Wallpapers & videos - Apps on Google Play23 abril 2025
-
RELEMBRE a TRETA que PAROU a TWITCH entre WAVE IGL TIBURCIO , FER E COLDZERA !!23 abril 2025
você pode gostar
-
Rossmann (company) - Wikipedia23 abril 2025
-
RBXNews on X: We recently rebranded our #Roblox Discord Server23 abril 2025
-
Cruel Summer chega à Prime Vídeo23 abril 2025
-
American Heart Health Month23 abril 2025
-
Slime Sam Sapeca e a PESSADÍSIMA SACOLA DE DOCES23 abril 2025
-
Pokémon completa mil episódios: confira 7 cenas marcantes do desenho23 abril 2025
-
Super Mercado El Local23 abril 2025
-
FNF Sunky Mod Test - Apps on Google Play23 abril 2025
-
The 19-year evolution of Steam23 abril 2025
-
Jogo Disney Princess BFFs Spree23 abril 2025