Pathophysiology, Free Full-Text

Diabetes Mellitus (DM) is a complex metabolic disorder associated with multiple microvascular complications leading to nephropathy, retinopathy, and neuropathy. Mounting evidence suggests that red blood cell (RBC) alterations are both a cause and consequence of disturbances related to DM-associated complications. Importantly, a significant proportion of DM patients develop varying degrees of anemia of confounding etiology, leading to increased morbidity. In chronic hyperglycemia, RBCs display morphological, enzymatic, and biophysical changes, which in turn prime them for swift phagocytic clearance from circulation. A multitude of endogenous factors, such as oxidative and dicarbonyl stress, uremic toxins, extracellular hypertonicity, sorbitol accumulation, and deranged nitric oxide metabolism, have been implicated in pathological RBC changes in DM. This review collates clinical laboratory findings of changes in hematology indices in DM patients and discusses recent reports on the putative mechanisms underpinning shortened RBC survival and disturbed cell membrane architecture within the diabetic milieu. Specifically, RBC cell death signaling, RBC metabolism, procoagulant RBC phenotype, RBC-triggered endothelial cell dysfunction, and changes in RBC deformability and aggregation in the context of DM are discussed. Understanding the mechanisms of RBC alterations in DM provides valuable insights into the clinical significance of the crosstalk between RBCs and microangiopathy in DM.

Cellular pathology, as based upon physiological and pathological histology. Twenty lectures delivered in the Pathological institute of Berlin during the months of February, March and April, 1858.

Pathophysiology Of Disease An Introduction To Clinical Medicine, 7th Ed [ PDF][tahir 99] VRG : Free Download, Borrow, and Streaming : Internet Archive

Calaméo - Pathophysiology 6th Edition Jacquelyn Banasik Test Bank

Pathophysiology Disease Process Study Note Template for

Wheater'S Basic Pathology Pdf Free Download - Colaboratory

Pathophysiology of joint pain. - Abstract - Europe PMC

Pathophysiology Made Incredibly Easy

Rapid Review Ser.: Rapid Review Pathology Revised Reprint : With STUDENT CONSULT Online Access by Edward F. Goljan (2011, Trade Paperback) for sale online

The American Journal of Pathology