Pharmaceuticals, Free Full-Text

Por um escritor misterioso

Last updated 31 março 2025

Sigma1 receptors (σ1Rs) represent a structurally unique class of intracellular proteins that function as chaperones. σ1Rs translocate from the mitochondria-associated membrane to the cell nucleus or cell membrane, and through protein-protein interactions influence several targets, including ion channels, G-protein-coupled receptors, lipids, and other signaling proteins. Several studies have demonstrated that σR antagonists block stimulant-induced behavioral effects, including ambulatory activity, sensitization, and acute toxicities. Curiously, the effects of stimulants have been blocked by σR antagonists tested under place-conditioning but not self-administration procedures, indicating fundamental differences in the mechanisms underlying these two effects. The self administration of σR agonists has been found in subjects previously trained to self administer cocaine. The reinforcing effects of the σR agonists were blocked by σR antagonists. Additionally, σR agonists were found to increase dopamine concentrations in the nucleus accumbens shell, a brain region considered important for the reinforcing effects of abused drugs. Although the effects of the σR agonist, DTG, on dopamine were obtained at doses that approximated those that maintained self administration behavior those of another agonist, PRE-084 required higher doses. The effects of DTG were antagonized by non-selective or a preferential σ2R antagonist but not by a preferential σ1R antagonist. The effects of PRE-084 on dopamine were insensitive to σR antagonists. The data suggest that the self administration of σR agonists is independent of dopamine and the findings are discussed in light of a hypothesis that cocaine has both intracellular actions mediated by σRs, as well as extracellular actions mediated through conventionally studied mechanisms. The co-activation and potential interactions among these mechanisms, in particular those involving the intracellular chaperone σRs, may lead to the pernicious addictive effects of stimulant drugs.

Antioxidative Properties of Acetylsalicylic Acid on Vascular Tissues From Normotensive and Spontaneously Hypertensive Rats

Prescription Drug Monitoring Programs (PDMPs), Drug Overdose

How To Sell a Fake Disease (And Then More Drugs)

Tamo-015 Google Drive - Colaboratory

Pharmaceuticals: Medical Science and Medical Industry. The Formation of the American Pharmaceutical Industry. Jonathan Liebenau. Johns Hopkins University Press, Baltimore, MD, 1987. x, 207 pp. $35. Henry E. Sigerist Series in the

Mirum Pharmaceuticals Presents Maralixibat Five-Year Transplant-Free Survival Data for Patients With PFIC2 at Digital International Liver Congress 2020

Insights on Antibiotics Market within the Pharmaceuticals Sector, Rising Prevalence of Infectious Diseases to Emerge as a Key Driver, Technavio

Assessment of Soil Moisture Uptake under Different Salinity Levels for Paddy Crop, Journal of Irrigation and Drainage Engineering

Premium Photo Flag of the south africa with tablets pharmacology developments in the field of pharmaceuticals medicines antibiotics painkillers and epidemics increase in drug usage