Veterinary Sciences, Free Full-Text

Por um escritor misterioso

Last updated 12 novembro 2024

Canine hemangiosarcoma (HSA) is a relatively common neoplasia, occurring mainly in the skin, spleen, liver and right atrium. Despite the numerous studies investigating the treatment of canine HSA, no significant improvement in survival has been achieved in the last 20 years. Advancements in genetic and molecular profiling presented molecular similarities between canine HSA and human angiosarcoma. It could therefore serve as a valuable model for investigating new and more effective treatments in people and dogs. The most common genetic abnormalities in canine HSA have been found in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and neuroblastoma RAS viral oncogene homolog (NRAS) pathways. Mutations are also found in tumor protein p53 (TP53), phosphatase and tensin homolog (PTEN) and cyclin dependent kinase inhibitor 2A (CDKN2A). Known abnormal protein expression could be exploited to trial new target treatments that could be beneficial for both canine and human patients. Despite the high expression of vascular endothelial growth factor (VEGF) and its receptor (VEGFR), no correlation with overall survival time has ever been found. In this review, we explore the most recent developments in molecular profiling in canine HSA and discuss their possible applications in the prognosis and treatment of this fatal disease.

Veterinary Sciences An Open Access Journal from MDPI

Thieme E-Books & E-Journals

Babatunde A. Salami, PhD on X: Fully-Funded DVSc Positions at University of Guelph ( 🇨🇦 Suitable for the 👩‍🎓students with background & research interest in Veterinary Medicine, Anatomic Pathology, Clinical

FREE Taster Course for Veterinary Science by OET Online

Animal Medical Center West

Veterinary Terminology Chart - Clinical Charts and Supplies

Proteome analysis of excretory-secretory proteins of Entamoeba histolytica HM1:IMSS via LC–ESI–MS/MS and LC–MALDI–TOF/TOF – topic of research paper in Veterinary science. Download scholarly article PDF and read for free on CyberLeninka open

PDF) Quantifying capture stress in free ranging European roe deer (Capreolus capreolus)

[1847-1915, Mills Wesley] on . *FREE* shipping on qualifying offers. A Text-book Of Animal Physiology, With Introductory Chapters On

A Text-book Of Animal Physiology, With Introductory Chapters On General Biology And A Full Treatment Of Reproduction, For Students Of Human And

Introducing a new chemically defined medium and feed for hybridoma cell lines – topic of research paper in Veterinary science. Download scholarly article PDF and read for free on CyberLeninka open science

Surprise Veterinarian Themed Sticker Pack- 20 Pack, For the person who really loves stickers or for a large group. Makes the perfect gift for Vet tech