Viruses, Free Full-Text
Por um escritor misterioso
Last updated 23 março 2025

The successful development of a chemoprophylaxis against SARS-CoV-2 could provide a tool for infection prevention that is implementable alongside vaccination programmes. Nafamostat is a serine protease inhibitor that inhibits SARS-CoV-2 entry in vitro, but it has not been characterised for chemoprophylaxis in animal models. Clinically, nafamostat is limited to intravenous delivery and has an extremely short plasma half-life. This study sought to determine whether intranasal dosing of nafamostat at 5 mg/kg twice daily was able to prevent the airborne transmission of SARS-CoV-2 from infected to uninfected Syrian Golden hamsters. SARS-CoV-2 RNA was detectable in the throat swabs of the water-treated control group 4 days after cohabitation with a SARS-CoV-2 inoculated hamster. However, throat swabs from the intranasal nafamostat-treated hamsters remained SARS-CoV-2 RNA negative for the full 4 days of cohabitation. Significantly lower SARS-CoV-2 RNA concentrations were seen in the nasal turbinates of the nafamostat-treated group compared to the control (p = 0.001). A plaque assay quantified a significantly lower concentration of infectious SARS-CoV-2 in the lungs of the nafamostat-treated group compared to the control (p = 0.035). When taken collectively with the pathological changes observed in the lungs and nasal mucosa, these data are strongly supportive of the utility of intranasally delivered nafamostat for the prevention of SARS-CoV-2 infection.

Capsid integrity detection of pathogenic viruses in waters: Recent progress and potential future applications - ScienceDirect

Serum-free microcarrier based production of replication deficient Influenza vaccine candidate virus lacking NS1 using Vero cells, BMC Biotechnology

How to Remove Virus from Laptop or PC Without Antivirus - EaseUS

Influenza A virus exploits transferrin receptor recycling to enter host cells
An RNA-dependent DNA polymerase, different from the known viral reverse transcriptases, in the chicken system. - Abstract - Europe PMC

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022

Ms Sposion Man Nsp Download Size - Colaboratory

Remove Viruses Detected (5) Pop-up Scam [Virus Removal]

Free Online Virus Scan

Avira Free Security Review

How to scan an Android phone for malware - Android Authority

Virus Structure, Anatomy & Function - Video & Lesson Transcript

Online Virus Scanner, Free Virus Scan

Panda Free Antivirus Review

Viruses, Free Full-Text
Recomendado para você
-
How Long Do Hamsters Live?23 março 2025
-
Winter white dwarf hamster - Wikipedia23 março 2025
-
New animal model to aid in the development of Covid-19 cure – The Childrens Post of India23 março 2025
-
How Long Do Gerbils Live? Gerbil Lifespan as Pets and in the Wild - LittleGrabbies23 março 2025
-
Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri, Parasites & Vectors23 março 2025
-
How Soon Can You Take a Hamster From Its Mother?23 março 2025
-
Hamster (Golden)23 março 2025
-
LIFE CYCLE of a GUINEA PIG Birth, Puberty, Reproductive Cycle23 março 2025
-
How Long Do HAMSTERS LIVE? 🐹 Average Hamster Life Expectancy23 março 2025
-
PPT - All About Hamsters PowerPoint Presentation, free download - ID:10810523 março 2025
você pode gostar
-
One Piece Logo Pixel Art by m0ng1990 on DeviantArt23 março 2025
-
trading checker in mm2|TikTok Search23 março 2025
-
Roblox Promo Codes 2023 - Get Free Robux - Roblox Codes 2023 [Video], 202323 março 2025
-
Drawful 2 for Nintendo Switch - Nintendo Official Site23 março 2025
-
Solved 3-37. The force F={6i+8j+10k}N creates a moment23 março 2025
-
Genshin Impact lançará atualização 3.8 em 5 de julho e visual de23 março 2025
-
☆ free gacha club ocs !! ☆23 março 2025
-
ROBLOX - Prime Bundle #3 (Hungry Orca, Fly Face, Clutch Missile, Evil Clown)23 março 2025
-
Roblox Piggy Skins List - All Characters & Outfits! - Pro Game Guides23 março 2025
-
Fishing Frenzy Simulator Codes23 março 2025