Viruses, Free Full-Text
Por um escritor misterioso
Last updated 24 abril 2025

Human cytomegalovirus (HCMV) tegument protein pp150 is essential for the completion of the final steps in virion maturation. Earlier studies indicated that three pp150nt (N-terminal one-third of pp150) conformers cluster on each triplex (Tri1, Tri2A and Tri2B), and extend towards small capsid proteins atop nearby major capsid proteins, forming a net-like layer of tegument densities that enmesh and stabilize HCMV capsids. Based on this atomic detail, we designed several peptides targeting pp150nt. Our data show significant reduction in virus growth upon treatment with one of these peptides (pep-CR2) with an IC50 of 1.33 μM and no significant impact on cell viability. Based on 3D modeling, pep-CR2 specifically interferes with the pp150–capsid binding interface. Cells pre-treated with pep-CR2 and infected with HCMV sequester pp150 in the nucleus, indicating a mechanistic disruption of pp150 loading onto capsids and subsequent nuclear egress. Furthermore, pep-CR2 effectively inhibits mouse cytomegalovirus (MCMV) infection in cell culture, paving the way for future animal testing. Combined, these results indicate that CR2 of pp150 is amenable to targeting by a peptide inhibitor, and can be developed into an effective antiviral.

What Is a Computer Virus?, Computer Virus Definition

How to Create a Virus: 9 Steps (with Pictures) - wikiHow

Free Virus Scanner 2023, Online Virus Scan

5 Best Free Online Virus Scanners & Removers for 2023

Molecular characterization of a new virus species identified in yam (Dioscorea spp.) by high-throughput sequencing

Viral persistence in children infected with SARS-CoV-2: current evidence and future research strategies - The Lancet Microbe

Viruses, Free Full-Text

Online Virus Scanner, Free Virus Scan

Sophos Home: Free antivirus for Windows and Mac users

How Do I Know If My Phone Has a Virus + Removing Them - Panda Security

File:Pathogenesis-of-Hepatitis-C-During-Pregnancy-and-Childhood-viruses-04-03531-g001.jpg - Wikimedia Commons
Recomendado para você
-
Mizumori Ado Japanese Visual Sheet Desk Padment24 abril 2025
-
This USB-C tester will tell you if your Apple chargers are genuine24 abril 2025
-
SCP-024, also known as the Game Show of Death is an abandoned sound st24 abril 2025
-
Alex Mercer vs SCP-096 #alexmercer #prototype #versus #scp09624 abril 2025
-
IFS700 IFS701 IFS703 IFS702 IFS707 IFS709 new and original24 abril 2025
-
Pre Order Shipped the 4 November Gameboy Advance Sp - Norway24 abril 2025
-
cod downed sound effect by vVrr Sound Effect - Meme Button - Tuna24 abril 2025
-
Fishdom Level 7141 - 7150 (First Try) 🐟24 abril 2025
-
Axnes AS on LinkedIn: #sar #hems #crew #lawenforcement #publicsafety24 abril 2025
-
SCP-524 SCP Foundation Amino24 abril 2025
você pode gostar
-
Trailer 2ª Temporada de Loki: Marvel anuncia retorno triunfal!24 abril 2025
-
Superman: The Movie (DVD, 2001, Widescreen) Brand New Sealed Christopher Reeve 1256910132624 abril 2025
-
Vampire: The Masquerade – Swansong: How to Win a Confrontation24 abril 2025
-
FIFA 22 Patch 4 Coming Soon For All Platforms - Patch Notes24 abril 2025
-
São Paulo 2 x 1 Corinthians Campeonato Brasileiro: melhores momentos24 abril 2025
-
I Played The Bongcloud Against Nakamura—And Survived (Almost)24 abril 2025
-
Óculos Juliet com armação metálica na cor preta e lentes polarizadas Uv400 na cor azul escuro.24 abril 2025
-
Roblox-Camiseta Bidimensional Infantil de Manga Curta, Roupa Fina de Algodão, Animação Periférica, Meninos e Meninas, Moda24 abril 2025
-
GO 79.9 Outdoor Sunbed w/ Adjustable Canopy, Gray Wicker24 abril 2025
-
The problem with tier 1124 abril 2025