The role played by alternative splicing in antigenic variability in
Por um escritor misterioso
Last updated 29 março 2025

Endo-parasites that affect humans include Plasmodium, the causative agent of malaria, which remains one of the leading causes of death in human beings. Despite decades of research, vaccines to this and other endo-parasites remain elusive. This is in part due to the hyper-variability of the parasites surface proteins. Generally these surface proteins are encoded by a large family of genes, with only one being dominantly expressed at certain life stages. Another layer of complexity can be introduced through the alternative splicing of these surface proteins. The resulting isoforms may differ from each other with regard to cell localisation, substrate affinities and functions. They may even differ in structure to the extent that they are no longer recognised by the host’s immune system. In many cases this leads to changes in the N terminus of these proteins. The geographical localisation of endo-parasitic infections around the tropics and the highest incidences of HIV-1 infection in the same areas, adds a further layer of complexity as parasitic infections affect the host immune system resulting in higher HIV infection rates, faster disease progression, and an increase in the severity of infections and complications in HIV diagnosis. This review discusses some examples of parasite surface proteins that are alternatively spliced in trypanosomes, Plasmodium and the parasitic worm Schistosoma as well as what role alternate splicing may play in the interaction between HIV and these endo-parasites.

The role played by alternative splicing in antigenic variability in

Frontiers Correlations Between the Characteristics of

Frontiers Response: Commentary: An In Silico–In Vitro Pipeline

The role played by alternative splicing in antigenic variability

Current perspectives on mass spectrometry-based immunopeptidomics

IJMS, Free Full-Text

Telomere and Subtelomere R-loops and Antigenic Variation in

Frontiers Immune Evasion Strategies of Relapsing Fever Spirochetes

Position-dependent effects of RNA-binding proteins in the context

The relevance of alternative RNA splicing to pharmacogenomics

INSPIRED Symposium Part 4B: Chimeric Antigen Receptor T Cell

The Expanding Landscape of Alternative Splicing Variation in Human
Recomendado para você
-
SWITCHBLADE Skull-T – Nomad Cigars29 março 2025
-
SCP-5812 Ghostyard Safe [SCP Document Reading]29 março 2025
-
SCP-7148 - SCP Foundation29 março 2025
-
introvertalert (u/introvertalert) - Reddit29 março 2025
-
PTFE Fabric Curbell Plastics29 março 2025
-
PDF) Biological Characteristics of Verticillium dahliae MAT1-1 and29 março 2025
-
424B429 março 2025
-
SCP-7148 Land of Milk and Honey Keter [SCP Document Reading29 março 2025
-
US20060160135A1 - SF-1 and LRH-1 modulator development - Google29 março 2025
-
The role played by alternative splicing in antigenic variability in human endo-parasites, Parasites & Vectors29 março 2025
você pode gostar
-
311 Live Wire Earth Wire Neutral Wire Images, Stock Photos, 3D objects, & Vectors29 março 2025
-
Community Created Web-Only Episodes That Even Fans Might29 março 2025
-
fnaf totaly real sb movie poster by weegeen8or1337 -- Fur Affinity [dot] net29 março 2025
-
Ichiban Ushiro no Dai Maou - Ending HD [720p]29 março 2025
-
High on Life PS5, PS4 Versions Out Now With New DLC Gameplay Trailer - PlayStation LifeStyle29 março 2025
-
Explore the Best Regigigas Art29 março 2025
-
Horizon Zero Dawn: The Frozen Wilds review29 março 2025
-
EURO 2024 play-offs: How they work, state of play, European Qualifiers29 março 2025
-
Ce surpriză! Improvizația FCSB-ului din atac pentru meciul cu Hermannstadt. Compagno nu e în lot29 março 2025
-
Vazamento revela que FIFA 23 terá parceria com a Marvel para29 março 2025