Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments
Por um escritor misterioso
Last updated 26 março 2025
The treatment of glioblastoma is challenging for the clinician, due to its chemotherapeutic resistance. Recent findings suggest that targeting glioblastoma using anti-cancer natural polyphenols is a promising strategy. In this context, curcumin and berberine have been shown to have potent anti-cancer and anti-inflammatory effects against several malignancies. Due to the poor solubility and limited bioavailability, these compounds have limited efficacy for treating cancer. However, use of a formulation of curcumin with higher bioavailability or combining it with berberine as a co-treatment may be proving to be more efficacious against cancer. Recently, we demonstrated that solid lipid curcumin particles (SLCPs) provided more bioavailability and anti-cancer effects in cultured glioblastoma cells than did natural curcumin. Interestingly, a combination of curcumin and berberine has proven to be more effective in inhibiting growth and proliferation of cancer in the liver, breast, lung, bone and blood. However, the effect of combining these drugs for treating glioblastoma, especially with respect to its effect on activating the PI3K/Akt/mTOR pathways has not been studied. Therefore, we decided to assess the co-treatment effects of these drugs on two different glioblastoma cell lines (U-87MG and U-251MG) and neuroblastoma cell lines (SH-SY5Y) derived from human tissue. In this study, we compared single and combination (1:5) treatment of SLCP (20 μM) and berberine (100 μM) on measures of cell viability, cell death markers, levels of c-Myc and p53, along with biomarkers of the PI3K/Akt/mTOR pathways after 24–48 h of incubation. We found that co-treatment of SLCP and berberine produced more glioblastoma cell death, more DNA fragmentation, and significantly decreased ATP levels and reduced mitochondrial membrane potential than did single treatments in both glioblastoma cells lines. In addition, we observed that co-treatment inhibited the PI3K/Akt/mTOR pathway more efficiently than their single treatments. Our study suggests that combination treatments of SLCP and berberine may be a promising strategy to reduce or prevent glioblastoma growth in comparison to individual treatments using either compound.

PDF) Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments

Nutrients, Free Full-Text

Curcumin suppresses glioblastoma cell proliferation by p-AKT/mTOR pathway and increases the PTEN expression - ScienceDirect

Regulated cell death (RCD) in cancer: key pathways and targeted therapies

Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt /mTOR pathway: go four better to treat bladder cancer, Cancer Cell International

IJMS, Free Full-Text

Inhibition of hepatocellular carcinoma growth via modulation of the miR-221/SOX11 axis by curcumin and berberine [PeerJ]

PDF] Solid Lipid Curcumin Particles Induce More DNA Fragmentation and Cell Death in Cultured Human Glioblastoma Cells than Does Natural Curcumin

PDF) Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments

Phytotherapy Research, Medicinal Chemistry Journal

Review on the Therapeutic Potential of Curcumin and its Derivatives on Glioma Biology
Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
Recomendado para você
-
IT Chara, Undertale 3D Boss Battles - ROBLOX Wiki26 março 2025
-
Churches Trumbull, CT - Last Updated November 2023 - Yelp26 março 2025
-
Amiss Car Charger Adapter, 6 USB Multi Port, Fast Charger, Include QC 3.0 and 5 Other Ports, Car Interior Accessories, Fit for iPhone 13/12/11/pro, Samsung Galaxy/Note S10/S9/S8, Android - Black26 março 2025
-
Student Life, April 16, 1920, Vol. 18, No. 27 by USU Libraries - Issuu26 março 2025
-
UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination26 março 2025
-
Metal recycling: opportunities, limited, infrastructure by United Nations Environment Programme - Issuu26 março 2025
-
Journal of Comparative Neurology, Systems Neuroscience Journal26 março 2025
-
Image 11 of The sun (New York [N.Y.]), September 26, 190126 março 2025
-
SCP-1000 - SCP Foundation26 março 2025
-
Bushnell Elite Tactical ERS 3.5-21x50 Riflescope G2 Reticle 34mm26 março 2025
você pode gostar
-
Meikyuu Black Company (The Dungeon of Black Company)26 março 2025
-
TGDB - Browse - Game - Tom Clancy's Splinter Cell: Double Agent26 março 2025
-
Bussoletti come scemi26 março 2025
-
Neither of us is ever fighting alone — Yamato's awareness of Taichi in Digimon Adventure26 março 2025
-
Becoming a Rich Slender in ROBLOX26 março 2025
-
Tic Tac Toe Glow - TMSOFT GAMES26 março 2025
-
IHOP® Menu - Kids Menu 12 And Under26 março 2025
-
Jetpacks 1g Pineapple Gelato Diamonds - California Cannabis Delivery, Fast and Easy26 março 2025
-
Sandals Grenada Resort & Spa Review: What To REALLY Expect If You Stay26 março 2025
-
Define Blunder, Blunder Meaning, Blunder Examples, Blunder Synonyms, Blunder Images, Blunder Vernacular, Blunder Usage, Blunder Rootwords26 março 2025