A somatization comorbidity phenotype impacts response to therapy
Por um escritor misterioso
Last updated 06 abril 2025

Background Comorbidities may contribute to disease activity and treatment response in rheumatoid arthritis (RA) patients. We defined a somatization comorbidity phenotype (SCP) and examined its influence on response to certolizumab pegol (CZP) using data from the PREDICT trial. Methods Patients in PREDICT were randomized to the patient-reported Routine Assessment of Patient Index Data 3 (RAPID3) or physician-based Clinical Disease Activity Index (CDAI) for treatment response assessment. Post-hoc analyses identified patients with the SCP, which included diagnosis of depression, fibromyalgia/myalgias, and/or use of medications indicated for treatment of depression, anxiety, or neuropathic pain. The effect of the SCP on RAPID3 or CDAI response at week 12 and low disease activity (LDA; Disease Activity Score in 28 joints based on erythrocyte sedimentation rate ≤ 3.2) at week 52, in week-12 responders, was analyzed using non-parametric analysis of covariance (ANCOVA). Results At baseline, 43% (313/733) of patients met the SCP classification. Patients with the SCP were 9% more likely to withdraw from the trial. American College of Rheumatology 20% (ACR20), ACR50, and ACR70 responses were 5–14% lower among those with the SCP, and 11% more patients reported adverse events (AEs). Patients without SCP in the CDAI arm were twice as likely to achieve LDA at week 52 compared with those with SCP (32% versus 16%). No differentiation by SCP was observed in the RAPID3 arm (pooled result 21.5%). Conclusions We operationalized a potentially important somatization comorbidity phenotype in a trial setting that was associated with a substantially lower likelihood of treatment response and a higher frequency of AEs. Including large numbers of patients with this phenotype in RA trials may reduce the measured clinical effectiveness of a new molecule. Trial registration ClinicalTrials.gov, NCT01255761 . Registered on 6 December 2010.

Somatic comorbidities in FGID patients (total FGID patients (effective

Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile – topic of research paper in Clinical medicine. Download scholarly article PDF and read for free on

Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders - Schiele - 2018 - Genes, Brain and Behavior - Wiley Online Library

Impact of predictive, preventive and precision medicine strategies in epilepsy

The translational genetics of ADHD and related phenotypes in model organisms - ScienceDirect

A somatization comorbidity phenotype impacts response to therapy in rheumatoid arthritis: post-hoc results from the certolizumab pegol phase 4 PREDICT trial, Arthritis Research & Therapy

Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression

Frontiers Editorial: Brain and Somatization Symptoms in Psychiatric Disorders

Frontiers Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness

Conversion Disorder: What Is It, Causes, Diagnosis, and More

Psychiatric comorbidities in TRD and non-TRD in UKB Psychiatric

Frontiers Insomnia – A Heterogenic Disorder Often Comorbid With Psychological and Somatic Disorders and Diseases: A Narrative Review With Focus on Diagnostic and Treatment Challenges

Biomedicines, Free Full-Text

Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study - The Lancet Digital Health
Recomendado para você
-
SCP-076, Monster Wiki06 abril 2025
-
female scp 076|TikTok Search06 abril 2025
-
Headstones: LIDDELL: Meehan Family History06 abril 2025
-
Galeria de Residência PDC / Central de Proyectos SCP - 706 abril 2025
-
Analysis and Control of Protein Crystallization Using Short06 abril 2025
-
Shin Megami Tensei: Devil Summoner 2 Part #16 - Kasumidai reached06 abril 2025
-
HPE SN3600B 1U RM Fibre Channel Managed Switch 16x32GbFC06 abril 2025
-
Professionally Evil Insights/Blogs06 abril 2025
-
Morgan back in November 2016… #MorganWallen #countrymusic #fyp06 abril 2025
-
AC Adapter for Hitron HEG42-240200-7L Power Supply Cord 37-0076-000 70-0499-10006 abril 2025
você pode gostar
-
Pin em ATIVIDADES COM NUMERAIS06 abril 2025
-
NBA: Harden bate marca histórica em Clippers x Warriors06 abril 2025
-
Resident Evil 4 remake - third trailer, demo, and DLC 'The Mercenaries' mode announced - Gematsu06 abril 2025
-
Starlost: Asteroid Mining image - ModDB06 abril 2025
-
Canal no apresenta filme dublado gratuito toda sexta-feira06 abril 2025
-
Season 02 Battle Pass and Bundles for Call of Duty: Modern Warfare II and Call of Duty: Warzone 2.0 — Call of Duty: Modern Warfare II — Blizzard News06 abril 2025
-
True Love Messages – Apps no Google Play06 abril 2025
-
Categoria:Dragões, Dragon Ball Wiki Brasil06 abril 2025
-
Brasil garante ouros no tênis e na canoagem slalom do Pan de Santiago - Acre Agora06 abril 2025
-
FOOTBALL HEADS 2014 : COPA LIBERTADORES jogo online no06 abril 2025