GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

PDF) Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

Frontiers CAR T Cell Therapy for Neuroblastoma

Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion - eBioMedicine

Vaccines, Free Full-Text

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research

Strategies to enhance CAR-T persistence, Biomarker Research

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice - ScienceDirect

Antigen density quantification of cell-surface immunotherapy targets by flow cytometry: Multi-antigen assay of neuroblastoma bone marrow metastasis - ScienceDirect

Membrane Proteome Array (MPA), Antibody Specificity Profiling

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Strategies to enhance CAR-T persistence, Biomarker Research