Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute
Por um escritor misterioso
Last updated 01 abril 2025

The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.

Self-propagation of pathogenic protein aggregates in

Marko KOSICEK, PhD, Ruđer Bošković Institute, Zagreb

The Neuropsychiatry of Niemann-Pick Type C Disease in Adulthood

A proposed model for the pathogenesis of Niemann-Pick disease type

Lysosomal dysfunction as a common mechanism of neurodegenerative

Niemann-Pick disease type C

PDF) BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick

JCM, Free Full-Text

PDF) Impaired Retromer Function in Niemann-Pick Type C Disease Is
Marko Košiček - Science communication coordinator - Ruđer Bošković

From genes to hope
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